The early comic books stretched across many genres, and the beginnings of the comic panels laid out in a format that wasn’t solely duplicated boxes was beginning to emerge. Text in the early comic books were still largely heavy, but the art was becoming more dynamic and synonymous to the text that was happening (nothing was just gag related or drawn out illustrations). Each panel is gaining more depth, with the drawings adding a layer of depth. The use of color as a means of storytelling becomes more experimental (especially in Tales of the Crypt as a means of injecting more horror into the story).
The biggest difference that emerged between the comic strip and the comic book was the condensed serialized stories that came within an issue rather than waiting for the next installment each week in the paper.
Tin Tin is an example of a contained story that mixes gags with a story that also mixes a small form of drama (or at least a conflict that provides multiple challenges for the protagonists). For example, the story Explorers on the Moon has multiple space related gags (the whiskey turning into a ball, the idea of anti-gravity, etc.) but is grounded in the rocket and the conflicts that can arise from it. EC comics, on the other hand, rely on very little (to no) gags, and instead the conflicts are rooted in the horror genre-where non-graphic violence is depicted in a way that was not meant to be a joke (as opposed to the more rubber-hose slapstick violence of some comic strips).
The early comic book was experimental. It pushed genre, and narrative boundaries that seemed to mix the drawn-out stories of the likes of Tarzan, with the visual appeal of more humorous strips.